Transdermal drug delivery systems: Analysis of adhesion failure

The most critical component of the TDDS is adhesive, which responsible for safety, efficacy and quality patch. For drug delivery to successfully occur, patch must adhere surface contact area. If a has inadequate adhesion, it likely fall off before entire period been satisfied, leading risks patient others who may encounter Despite concerns associated with adhesive properties patches, adhesion failure mechanisms have not fully studied. certain molecules cause irreversible altering its chemical composition, could render unsuitable transdermal applications. In many cases failure, sweat believed be culprit causing failure. goal this project investigate composition layer sample Sandoz Estradiol Transdermal System manufactured by Noven Pharmaceuticals, Inc., designed deliver 0.1mg per day contains 1.56mg USP, active ingredient. By analyzing that worn, versus possible determine interaction causes Fourier Transform Infra-Red (FTIR) Spectroscopy (OPUS FTIR Spectrometer) was performed on an unused estradiol immediately after opening, again 24 hours in ambient air potential oxidation. IR Spectrum then analyzed, peaks were reviewed. Spectra left out indicated lengthened corresponding C=O, C-O, O-H, decreased transmittance, wider bandwidth those regions. Based these results, can determined oxidation does occur exposed air. future works, additional samples will collected used extensive UV analysis. comparing graphs “used” patches did fail, “failed” identify premature related interactions.